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Blood Tests for Cancer Detection: What They Can and Can’t Tell You
Cancer is one of the world’s leading health concerns. An early diagnosis remains an essential factor to improve the survival rates and treatment outcomes. Over the years, blood tests have emerged as a key tool in the search for better, accurate, and accessible cancer detection methods. From traditional laboratory tests to advanced liquid biopsies, these tests helped to transform how oncologists used to screen for cancer, assess the risk, and monitor cancer patients over time!
In this article, we’ll delve more into the science behind the cancer-related blood tests, their types, how they reveal cancer, and where they fall short in bringing accurate results!
Why blood tests are used in Cancer diagnosis
Blood is one of the most versatile sources of health information in the body. It flows through every organ and tissue, carrying several nutrients, hormones, proteins, waste products, and even genetic fragments as well. When something ‘abnormal’ like cancer is happening in the body, it often leaves detectable signs in the body.
In most cases, doctors use these tests for three major reasons in cancer care:
- To detect signs that cancer may present
- To determine how well organs are functioning
- To understand any known cancer before, during or after cancer treatment
These tests can help to guide decisions long before imaging or biopsies come into play. However, these are never used as the only diagnostic tools confirming the cancer.
What blood tests can tell you about
Here’s what these tests can explain about people’s health, including:
Detect Tumor markers linked with certain cancers
Tumor markers are substances, often known as proteins, produced either by the cancer cells or present in the body's response to the cancer. An increased level of these tumor markers can be a warning sign.
Here are some of the most common tumor markers include:
- PSA (Prostate-Specific Antigen)
- CA-125
- AFP
- CEA
- CA 15-3/ CA 27.29
High levels of these tumor markers do not confirm cancer; they signal that further diagnostic testing may be needed.
Provide important clues about Organ and Tissue health
Cancer can disrupt the normal functioning of organs. Here are some of the routine tests:
- Complete Blood Count (CBC)
- Liver function tests (LFTs)
- Kidney function tests (BUN/creatinine)
- Electrolyte panels
These can reveal the several abnormalities that suggest cancer that might be affecting the liver, kidneys, bone marrow, or other systems.
For example:
- Low red or white blood cell counts can point to leukemia or bone marrow cancer.
- Increased liver enzymes might suggest metastatic cancer affecting the liver.
- Abnormal calcium levels could indicate bone-related cancer or metastasis.
These clues are helpful, but these tests only won't confirm cancer-specific links accurately.
These tests can analyze circulating Tumor DNA (ctDNA)
Currently one of the most exciting developments in cancer research is the liquid biopsy, which looks for DNA pieces shed from tumors into the bloodstream.
These liquid biopsies can help with:
- These tests can detect mutations that help identify several cancers
- Tests helps to guide targeted therapies
- Track how a tumor is growing
- It helps with recurrence earlier than imaging in some cases
Although these are not considered a universal diagnostic tool for cancer diagnosis. However, ctDNA tests are rapidly improving and have potential for the future of early detection.
These tests help monitor treatment responses
For patients diagnosed with cancer, performing these tests are considered vital during the cancer treatment. Many doctors use them to:
- Track tumor marker levels in the blood.
- Monitor organ function during chemotherapy treatments.
- Measure immune or inflammatory responses.
- These tests help to detect signs of recurrence after remission.
In some tests, the changes in bloodwork often help to reveal how well a treatment is working long before any scans do.
What blood tests can’t tell about Cancer
Performing only blood tests has significant limitations in cancer diagnosis. Misunderstanding these limitations can lead to unnecessary fear or misplaced confidence in people with suspicion of cancer.
Blood tests can’t only diagnose cancer on their own
This is the most important part of cancer diagnosis, because you can’t verify cancer diagnosis with test results.
Even if a test results shows:
- An increased tumor markers,
- Abnormal organ activities
- Suspicious DNA fragments
These won’t only prove cancer is present, there are some of the non-cancerous conditions such as infections, stress, pregnancy, liver disease, inflammation, or benign growths, which can cause abnormal results.
A definitive cancer diagnosis always requires:
- Physical examination
- Complete imaging (MRI, CT, PET or Ultrasound)
- A tissue biopsy
These tests can trigger further investigation but can’t confirm the cancer alone.
A blood tests can’t show the Exact Location of Cancer
Even blood cancer can predict the likelihood of cancer in a patient. But unfortunately, it can’t tell the oncologist about:
- Where the tumor is located
- The size of the tumor
- Whether it has spread in the bodies
- Stage of the cancer
All of this information can be confirmed through further tests and examinations in patients.
It can’t Detect all cancer types
Not all types of cancer release a particular biomarker into the bloodstream. There are types of cancers in the initial stages which produce little to no detectable symptoms.
These tests usually struggle to identify:
- Early-stage cancer
- Small, slow-growing tumor
- Types of breast, lung, and gastrointestinal cancers
- Some lymphomas and sarcomas
This often means a normal blood test does not guarantee that someone is or is not cancer-free!
Blood tests results can’t differentiate between Benign and Malignant Tumors
Here’s how:
- PSA can increase due to a prostate infection or enlargement, not just cancer.
- CA-125 can increase during the menstruation period, pregnancy, or pelvic inflammation.
- AFP can also increase in non-cancers
- These tests suggest an abnormal activity but can’t determine whether a growth is cancerous.
The Future of Blood based Cancer diagnosis
There is a lot of research happening in the landscape of blood-based cancer diagnosis and its scopes.
There are several technologies that are being developed, such as:
Multi cancer early detection (MCED) Tests
These tests aim to diagnose various cancers at once by analyzing DNA, proteins, and other blood components. These tests are not yet used as a widespread diagnostic tool. These often represent a future where cancer screening might become as simple as an annual blood test.
More sensitive liquid biopsies
While next generation liquid biopsies may eventually:
- Helps to detect very early stage cancers
- Reveal tumor origin with high accuracy rates
- Reduce the need for an invasive biopsies
Although the technology is still evolving, it offers more hope for earlier detection and better treatment outcomes.
How to use these tests wisely
Performing these tests on suspected cancer patients has both strengths and limitations, and it's important to consider it as part of a broader health strategy rather than a standalone screening test.
Talk to your healthcare professional
If you are worried about cancer or have a family history of cancer, then speak to a physician who you can recommend this:
- Appropriate cancer screening tests
- Genetic counseling
- Risk assessments
- Lifestyle changes
- Preventive steps
Do not panic over isolated and abnormal test results. There are many factors that are unrelated to cancer, and they can influence blood test values. There is follow-up testing, which is usually required to interpret results correctly.
Use blood tests as a complementary tool
Performing blood-related tests is a small part of the cancer diagnosis. These tests are considered most effective in cancer detection when combined with other diagnostic tests like imaging, physical examinations, and the personal medical history of a patient.
Consult Today
Performing blood tests has increasingly become a valuable part of modern cancer care. It offers valuable insights about cancer, which can guide early investigation, support cancer diagnosis, and monitor cancer treatments. These tests help oncologists and alert them to any unusual activity and reveal how well organs are functioning.
At Oncare, we offer premium-quality cancer treatments, including advanced cancer surgeries at an affordable price range with an experienced cancer specialist consultation.
If you or any loved ones of yours are diagnosed with cancer, then visit Oncare Cancer Center and book an appointment with our experienced cancer specialist today! Get an estimated cost of your cancer treatment today!
Frequently Asked Questions
Ans: Here are the different blood tests used for cancer, including:
- Complete blood count (CBC)
- Tumor marker blood tests
- Blood protein tests
- Circulating tumor cell tests
Ans: Here’s how cancer blood test work, including:
- Chemicals and proteins in your blood that might indicate cancer
- Blood cell levels that are too high or too low, because of cancer
- Stage of cancer
- Effectiveness of cancer treatments
- Whether cancer has come back or not (recurrence)
Ans: Here are some of the cancers detected through blood tests, including:
- Hodgkin Lymphoma
- Non-Hodgkin Lymphoma
- Leukemia
- Multiple Myeloma
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